Science
5 min read
The Promising Science and Future of NAD+ Supplements
As the research around nicotinamide adenine dinucleotide continues to expand, we can harness healthy doses to produce tangible benefits to your daily cellular function right now. This is the power CALERIE® can provide to your longevity diet.
CALERIE® Key Intakes:
  • NAD+ is a natural enzyme that occurs in our cells during many of our biological processes. Because NAD+ production decreases as we age, mimicking NAD+ production through a supplement can have a powerful effect on restoring our cellular health.
  • NAD+ supplements work best alongside a longevity diet packed with necessary vitamins and nutrients. The science of NAD+ has shown that adding NAD+ supplements to a longevity diet can decrease outward and internal signs of aging.
Did you know?
A vitamin is an organic molecule (or related set of molecules) that is an essential micronutrient that an organism needs in small quantities for the proper functioning of its metabolism.

In recent years, the potential of NAD+ to benefit human health has expanded beyond clinical trials and research labs into the form of NAD supplements. Biologists are increasingly fascinated by the role these enzymes have in our biological processes. Through innovations in anti-aging science, we have learned more about the efficacy of increased levels of NAD+ to activate and restore our cellular health.

NAD supplements can be key players in reducing the risk of age-related conditions. Prominent scientists are studying the use of NAD in relation to  cholesterol, blood pressure, heart health, and other cardiovascular ailments. The ability of NAD+ to increase lifespan by possibly reducing risk factors has excited Nobel laureates, providers, and prominent figures in national institutes across the world.

In comparison to traditional dietary supplements, NAD+ is proving to be a more effective addition to a longevity and weight management diet. The NR and NMN precursors are necessary for boosting the NAD levels that are essential to healthy, living cells. 

With the right concentration of NAD, we have the potential to transform how healthy middle-aged and older adults experience aging.

What is NAD+?

Nicotinamide adenine dinucleotide (NAD+) appears during the human cellular energy production process. NR and NMN are necessary precursors to NAD+ production, and as older adults age, we experience enzyme deficiency that leads to outward signs of the aging process like fine lines and wrinkles, inflammation, and other age-related concerns.

Most dietary supplements do not attempt to prevent these changes happening in our molecules. But to those who have studied the role of NAD, NMN, and NR supplements have in repairing DNA damage, NAD is an exciting development in the realm of anti-aging science. At CALERIE®, we have seen in clinical trials the possibility of NAD supplements preventing age-related conditions without side effects.

Why is NAD+ important?

Clinical research shows that NAD+ has a unique ability to protect tissues, induce DNA repair, boost cognition, prevent weight gain, and increase longevity. NAD+ can play a key role in transferring energy released from glucose and fatty acids to the mitochondria so that it can be converted into energy production.

NAD+ levels decline as we age, and a depletion of these necessary enzymes can lead to a variety of issues and risk factors, including metabolic dysfunction, metabolic disorders, and neurodegenerative issues. 

At the cellular level, we have seen how NAD levels are essential to our molecules, and therefore understand how they are also essential to our overall health.

What are Nicotinamide riboside (NR) and Nicotinamide mononucleotide (NMN)?

NR and NMN are an alternative form of vitamin B3, also called niagen or niacin. They are NAD precursors, meaning they go through chemical processes to become the natural compound NAD+. NMN is converted into NAD+, a helper coenzyme that fuels many of the biological processes of mammals and is essential to energy production.

NMN and NR supplements instigate NAD production in mammals. They are essential in cellular health and mitochondrial function.

What are the health concerns surrounding Nicotinamide adenine dinucleotide deficiency?

NAD+ deficiency can lead to major problems like cardiovascular, insulin sensitivity, inflammation, and loss of skeletal muscle. Decreased presence of the NAD precursor NMN also can lead to increased likelihood of obesity, cell death, decreased metabolism, and overall health degradation.

NR or NMN precursor supplements can help reduce the risk of many age-related issues that occur in the aging process. Clinical trials have shown NAD boosters to help in prevention and better aging.

How does CALERIE® help with weight management?

CALERIE® instigates the activity of sirtuins to promote more cellular NAD production. For those desiring weight loss or obesity prevention, CALERIE® helps suppress appetite during periods of fasting.

Previous studies have shown CALERIE® to reduce cravings and balance the cellular variables that impact energy consumption. Improved metabolic function, boosted NAD metabolism, and reduced oxidative stress are among the benefits of CALERIE® paired with a low-carbohydrate, high-nutrient, high-fat diet.

What role does NAD+ play in aging?

As we age, our bodies NAD production decreases because our cells lose the ability to repair themselves. Recent studies have suggested that increasing nad levels after natural decline of NAD is one of the best anti-aging treatments. NAD boosters paired with multivitamins and proper nutrients can slow the aging process and reduce risk factors.

Other dietary supplements do not consider how our cellular metabolism and mitochondria health are the foundation of our energy production processes. NAD is an essential enzyme to our cellular systems, and NAD boosters can be a powerful player in combating the aging process.

Why are NAD+ supplements so popular?

In the United states, NAD supplements are becoming increasingly popular because of previous results in animal studies that have shown the effectiveness in raising NAD+ levels in rodents and old mice. NAD+ capsules can be used as both anti-aging supplements and as weight management and energy metabolism boosters, and the breadth of the benefits of sirt1 activity in mammalian cells has been observed across mouse studies.

What is the recent research surrounding NAD+ and Sirtuin Activators?

Animal research has shown NAD+ to contribute to longevity. Clinical studies have shown that a daily dose of NAD+ supplements in mammals can stimulate the multiple biological processes that are fueled by the coenzyme. Further studies are being done to understand NAD role in increasing longevity.

What is the future of NAD+ Science?

NAD+ science has already provided us with valuable clinical trials, animal research, and rodents and mouse studies that are continuing to teach biologists about the role sirtuin activity can play in increasing life span. Overall, the efficacy NMN has in restoring healthy cellular metabolism is clear. 

Although NAD supplements have not been approved by the FDA, their lack of negative side effects has built researchers’ confidence in NAD supplements to have a promising future as effective anti-aging remedies.

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