Nicotinamide adenine dinucleotide (NAD+) is a molecule that appears during the human cellular energy production process. As older adults age, they experience NAD+ deficiency that leads to outward signs of the aging process like fine lines and wrinkles, chronic inflammation, and other age-related health concerns.
NMN is an alternative form of vitamin B3. They are NAD precursors, meaning they go through chemical processes to become the natural compound NAD+. NMN is converted into NAD+, a helper coenzyme that fuels many of the biological processes of mammals and is essential to energy production. NMN supplements instigate NAD production in mammals. They are essential in cellular health and mitochondrial function.
NAD+ deficiency can lead to major problems like cardiovascular conditions, insulin sensitivity, chronic inflammation, and loss of skeletal muscle. Decreased presence of the NAD precursor NMN also can lead to increased likelihood of obesity, cell death, decreased glucose metabolism, and overall degradation. NMN precursor supplements can help reduce the risk of many age-related conditions that occur in the aging process. Clinical trials have shown NAD boosters to help in prevention.
As we age, our bodies NAD production decreases because our cells lose the ability to repair themselves. Recent studies have suggested that increasing NAD levels after natural decline of NAD is one of the best anti-aging treatments. NAD boosters paired with multivitamins and proper nutrients can slow the aging process and may reduce the risk of metabolic conditions. Other dietary supplements do not consider how our cellular metabolism and mitochondria health are the foundation of our energy production processes. NAD are essential enzymes to our cellular systems, and NAD boosters can be a powerful preventative in combating the aging process.
CALERIE® instigates the activity of sirtuins to promote more cellular NAD production. For those desiring weight loss or obesity prevention, CALERIE® helps suppress appetite during periods of fasting. Previous studies have shown CALERIE® to reduce cravings and balance the cellular variables that impact energy consumption. Improved metabolic function, boosted NAD metabolism, and reduced oxidative stress are among the benefits of CALERIE® paired with a low-carbohydrate, high-nutrient, high-fat diet.
In the United states, nicotinamide mononucleotide supplements are becoming increasingly popular because of previous results in animal studies that have shown the effectiveness in raising NAD+ levels in rodents and old mice. NAD+ capsules can be used as both anti-aging supplements and as weight management and energy metabolism boosters, and the breadth of the benefits of sirt1 activity in mammalian cells has been observed across mouse studies.
Animal research has shown NAD+ to contribute to longevity. Clinical studies have shown that a daily dose of NAD+ supplements in mammals can stimulate the multiple biological processes that are fueled by the coenzyme. Further studies are being done to understand NAD role in increasing longevity.
Clinical studies reveal that N-acylethanolamines can influence immune reactions in various autoimmune disorders, via different receptors and metabolic pathways. The N-acylethanolamine palmitoylethanolamide (PEA) interacts with the cannabinoid receptors CB1R and CB2R and modulates mast cells. Mast cells are immune cells that exhibit immunoregulatory and pro-inflammatory functions in immune disorders. PEA effects in the body include preventing mast cell responsiveness to damage sites and inhibiting mast cell granule loss in pathological conditions. PEA is an agonist of the PPAR-α receptor, which exists in many organs, tissues, and immune cells and participates in inflammatory processes.
Researchers examine how PEA associates with mast cells, glial cells, and the PPAR-α receptor, all of which exhibit pro-inflammatory effects and conduct clinical trials to investigate the anti-inflammatory effects of PEA on chronic pain and neuropathic pain. Mast cells, which can infiltrate the thalamus and spinal cord, send pro-inflammatory signals to glial cells. Glial cells are sources of pro-inflammatory molecules that have critical roles in neuropathic pain and neurodegenerative diseases. The findings of clinical studies suggest the endogenous fatty acid amide PEA plays an important role in inhibiting pro-inflammatory molecules, the maintenance of chronic pain, and reducing pain intensity.
Leg and muscle cramps can be symptoms of various neuropathies or diseases such as diabetes or liver disorders. The American Heart Association reports that painful muscle cramps in the hips, thighs, or calves are common symptoms of peripheral artery disease, associated with heart attacks and cardiac arrest. Findings from clinical trials led some researchers to conclude that some beneficial PEA effects include PEA’s ability to relax muscles and stabilize overactive muscles naturally. A recent study detailing a literature review of PEA, a clinical trial of PEA treatment, and case reports of older adults experiencing chronic pain and neuropathic pain indicates the beneficial effects of PEA treatment in alleviating muscle cramps.
Neuroinflammation in the human brain relates to injuries, infections, neurodegenerative diseases, aging, and other situations, in which the brain’s immune system tries to protect brain function and structure. The initiation of neuroinflammation serves to fight against threats to brain function and health, but the triggering of inflammation can cause chronic pain and injury. According to research, increased PEA levels contribute to diminishing neuroinflammation caused by glial cell activation. The findings of animal studies and models and clinical trials used to investigate the role of PEA in neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease suggest that there are neuroprotective PEA effects.
Some supplements try to claim health benefits through weight loss alone, but CALERIE® focuses on how we process energy at the cellular level.
It’s no secret that diet and exercise are the best ways to improve health and wellness. However, recent research shows that we may be able to mimic the benefits of exercise and caloric restriction on cellular metabolism with the use of NAD+ boosters and Sirtuin activators.
NAD+ can work as a natural appetite suppressor and exercise and fasting mimetic, making it a popular supplement for athletes and individuals implementing paleo, keto, or low-carb, high-fat diets. Trace amounts of NMN and NR can help with cellular repair, making CALERIE® an excellent supplement to add to a longevity diet or a weight loss and exercise program.
With CALERIE®, we intervene at the cellular level to mimic NAD production and help promote wiser, healthier weight management.
PEA, a fatty acid amide, belongs to the N-acylethanolamine family. There are many PEA plant and food sources, as animals, humans, and plants produce PEA endogenously. PEA is also an agonist of PPAR-α; PPAR-α is a transcription factor that regulates the energy metabolism of lipids, amino acids, and carbohydrates. The effects of PEA include anti-inflammation and neuropathic and chronic pain relief.
The body naturally produces PEA when experiencing chronic pain, neuropathic pain, psychological and physical stress, and viral and bacterial infections. The phospholipids comprising all cell membranes synthesize PEA, making PEA abundant in the body and efficiently available to every cell. The metabolic pathways of PEA involve hydrolysis by NAPE-PLD and degradation by fatty acid amide hydrolase (FAAH).
Clinical studies demonstrate how the endocannabinoid system helps the body defend itself against infections, stress, pain, inflammation, and other damage. The body produces the endocannabinoids AEA and 2-AG, which act on the CB1R and CB2R receptors. 2-AG is similar in chemical structure to PEA. While PEA and 2-AG are structurally similar, PEA doesn’t bind to CB1R and CB2R the way 2-AG does. PEA takes indirect action on receptors associated with pain signal transfers. By interacting with the cannabinoid receptors CB1R and CB2R, PEA, a PPAR-α agonist, can reduce pain intensity. Activating PPAR-α enables PEA to stop pro-inflammatory gene activity and the production of inflammation-causing substances.
Clinical studies reveal the potential beneficial effects of PEA on neuropathic pain and chronic pain conditions such as osteoarthritis, fibromyalgia, lower back pain, and carpal tunnel syndrome. The demonstrated anti-inflammatory effects of PEA lead some researchers to suggest that PEA treatment can be useful in standard therapies for chronic pain and neurodegenerative conditions. Increasing the PEA and NAD levels in the body allows people to harness the effects of PEA and treat pain without experiencing serious side effects.