CALERIE is an acronym

It stands for Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy.

Clinical trials and animal studies have shown that for most species, if you restrict the number of calories consumed, the organisms live longer.

In fact, calorie restriction (CR) is the only consistent intervention known to increase life span.

At CALERIE® we believe in the ability of caloric restriction (CR) to instigate weight loss and increase longevity in humans. Our rationale is supported by the successful outcomes in participants who partook in the extensive research projects of the unaffiliated two-year clinical trial at Duke University.

CALERIE® promotes calorie restriction (CR) as an integral practice in balanced cellular health and the instigation of healthy weight loss.

With CALERIE®, we intervene at the cellular level to boost NAD+ production and help promote wiser, healthier weight management.


Assessment of


Effects of


Intake of



CALERIE began as the first U.S. clinical trial to investigate the impacts of sustained calorie restriction in primates. The two phases of CALERIE study concluded caloric restriction to instigate weight loss, reduce risks of cardiovascular disease and chronic disease, and contribute to a significant reduction in negative effects of the aging process.

The secondary outcomes and health effects of CR ranged from improved body composition, reduced oxidative stress, increased immune function, lowered glucose levels, improved cognitive function, and long-term reduction to risks of obesity and early morbidity.

The clinical trial showed minimal risk factors and no reduction to quality of life in humans.

CALERIE was the first study of its kind to take an intensive behavioral approach to objectively measuring caloric restriction’s impacts on biologic effects through a randomized controlled trial.

CALERIE participants were healthy, nonobese humans of various gender and ethnic groups. Participants conformed to dietary modifications including, but not limited to, limited calorie intake, reduced portion size, specific meal plans, and low-carbohydrate diets.
CALERIE participants incorporated particular behavioral strategies, group counseling sessions, and social support networks as a part of their participation in the calorie restriction group.

Researchers used the intake balance method to calculate energy intake from the difference between changes in energy stores (assessed by dual energy X-ray absorptiometry) and total energy expenditure (TEE) assessed by the doubly-labeled water method.
The full CALERIE data set is summarized and available online.

Disclaimer: CALERIE Supplements is not affiliated with the CALERIE clinical study.

Read More About CALERIE®
6 mins
Supplements That Mimic Calorie Restriction
The 5 Stages of Intermittent Fasting
Loading cart ...